Endocrine Abstracts

The 25-hydroxyvitamin D (25OHD) serum concentration is the marker of vitamin D status. It is measured by immunoanalysis, mostly on automated platforms, or by separative methods such as HPLC or LC/MS-MS. An important inter-method variability has been evidenced some years ago. This has however improved recently thanks to the availability of an international standard and of a reference method (RM), and to the implementation of the Vitamin D Standardization Program (VDSP). Some pr...

Introduction: Parathyroid carcinoma (PCa) is a rare presentation of primary hyperparathyroidism (PHPT), accounting for less than 1% of cases. Differentiating parathyroid cancer from benign hyperparathyroidism is clinically challenging. Some previous work suggest that there is a paraneoplastic hCG production in parathyroid cancer (Stock et al 1987, Rubin et al 2008). In this study, we aimed to investigate whether the hCG+β kit from Roche Diagnostics could distinguish PCa p...

Objectives: X-linked hypophosphatemic Rickets (XLHR) is characterized by phosphate wasting and decreased production of 1,25OH-vitamin D, due, in most patients, to elevated FGF23 and PHEX mutation. In children, the disease has been extensively studied because of the devastating presentation of rickets, teeth abcesses, and growth retardation. In adults, however, metabolic complications, such as hyperparathyroidism or consequences on glucose and lipid metabolism of FGF23 excess, ...